Understanding familial and non-familial renal cell cancer
نویسندگان
چکیده
منابع مشابه
Understanding familial and non-familial renal cell cancer.
Molecular genetic analysis of familial and non-familial cases of conventional renal cell carcinoma (RCC) revealed a critical role(s) for multiple genes on human chromosome 3. For some of these genes, e.g. VHL, such a role has been firmly established, whereas for others, definite confirmation is still pending. Additionally, a novel role for constitutional chromosome 3 translocations as risk fact...
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Objective Globozoospermia is a rare syndrome with an incidence of less than 0.1% among infertile men. Researchers have recently identified a large deletion, about 200 kbp, encompassing the whole length of DPY19L2 or mutations in SPATA16 and PICK1 genes associated with globozoospermia. The aim of this study was to analyze the DPY19L2 gene deletion using polymerase chain reaction technique for th...
متن کاملFamilial renal cell cancer appears to have a recessive component.
R enal cell cancer (RCC) accounts for 80–90% of all cancers of the kidney. Clear cell carcinoma is the most common cell type among parenchymal adenocarcinomas. 3 Over 2% of Swedish RCC patients have a parent with RCC, and the familial risk has been about 1.6. 5 RCC is a manifestation in von Hippel Lindau (VHL) syndrome, in which up to one half of the mutation carriers of the VHL gene are though...
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PURPOSE An overwhelming majority of data on familial risk in cancer is based on incident cancer, whereas familiality in cancer mortality is largely unknown. If fatal form of cancer was a highly familial subtype, then familial risk for mortality may exceed that of incidence, which would be particularly relevant for clinical decision making and counseling. PATIENTS AND METHODS The individuals i...
متن کاملFamilial renal insufficiency.
The picture of chronic renal insufficiency in childhood is not common, and instances of more than one member of a family with this picture are comparatively rare. Mitchell (1930), in an exhaustive review of the literature of chronic interstitial nephritis in childhood, quotes 14 instances in which more than one child in the family was affected. Graham and Hutchinson (1941) have described a fami...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2002
ISSN: 1460-2083
DOI: 10.1093/hmg/11.20.2489